Genome Wide Association Study Of Vitamin B6

Genome-wide Association Study of Vitamin B6,.

Genome-wide Association Study of Vitamin B6, Vitamin B12, Folate, and Homocysteine Blood Concentrations Toshiko Tanaka,1,2 Paul Scheet,3 Betti Giusti,4 Stefania Bandinelli,5 Maria Grazia Piras,6 Gianluca Usala, 6Sandra Lai, Antonella Mulas,6. Seven compounds of vitamin E were quantified in sweet corn kernels at 28 days after pollination. A total of 119 loci for vitamin E were identified using a genome-wide association study based on genotyping by sequencing, and a genetic network of vitamin E was constructed. 23/04/2010 · In a genome-wide association study GWAS of 4501 persons of European ancestry drawn from five cohorts, we identified single-nucleotide polymorphisms SNPs in the gene encoding group-specific component vitamin D binding protein, GC, on chromosome 4q12-13 that were associated with 25OHD concentrations: rs2282679 P = 2.0 × 10 −30, in.

13/06/2019 · Methods. We conducted a genome-wide association study GWAS using 5962 genome-wide markers, acquired from 96 core sesame accessions. The GWAS was performed using generalized linear GLM and mixed linear MLM models. To investigate genetic factors that affect circulating vitamin B6, vitamin B12, folate and homocysteine, a genome-wide association analysis was conducted in the InCHIANTI N = 1175, SardiNIA N = 1115, and BLSA N = 640 studies. The top loci were replicated in an independent sample of 687 participants in the Progetto Nutrizione study. Experimental, observational, and clinical trials support a critical role of folate one-carbon metabolism FOCM in colorectal cancer CRC development. In this report, we focus on. 05/07/2011 · Abstract. In genome-wide association studies GWAS of common genetic variants associated with circulating alpha- and gamma-tocopherol concentrations in two adult cohorts comprising 5006 men of European descent, we observed three loci associated with alpha-tocopherol levels, two novel single-nucleotide polymorphisms SNPs, rs2108622 on 19pter.

Genome-wide Association Study of Vitamin B6, Vitamin B12, Folate, and Homocysteine Blood Concentrations DOI: 10.1016/j.ajhg.2009.02.011. 16/07/2013 · Genome-wide association studies have the potential to identify causal genetic factors underlying important phenotypes but have rarely been performed in bacteria. We present an association mapping method that takes into account the clonal population structure of bacteria and is applicable to both core and accessory genome variation. Genome-Wide Association Study of Circulating Vitamin D Levels The Harvard community has made this article openly available. Please share how this access benefits you. Genome-wide Association Study of Vitamin B6, Vitamin B12, Folate, and Homocysteine Blood Concentrations, Am J Hum Genet. 2009. Ebben M, Lequerica A, Spielman A 2002. "Effects of pyridoxine on dreaming: a preliminary study ". 04/03/2019 · The active form of vitamin B6, pyridoxal phosphate PLP, is essential for human metabolism. The brain is dependent on vitamin B6 for its neurotransmitter balance. To obtain insight into the genetic determinants of vitamin B6 homeostasis, we conducted a genome-wide association study GWAS of the B6 vitamers pyridoxal PL, PLP and.

  1. 10/04/2009 · Genome-wide significant associations were observed for vitamin B6, B12, and homocysteine concentrations. Vitamin B6 was only measured in the InCHIANTI study, thus the GWA of 484,115 autosomal SNPs was assessed with a Bonferroni corrected p value threshold of 1 × 10 −7 Figure 1 A and Figure S1 available online.
  2. 10/04/2009 · The B vitamins are components of one-carbon metabolism OCM that contribute to DNA synthesis and methylation. Homocysteine, a by-product of OCM, has been associated with coronary heart disease, stroke and neurological disease. To investigate genetic factors that affect circulating vitamin B6, vitamin B12, folate and homocysteine, a genome-wide.
  3. 15/05/2009 · Genome-wide Association Study of Vitamin B6, Vitamin B12, Folate, and Homocysteine Blood Concentrations. This corrects the article "Genome-wide Association Study of Vitamin B6, Vitamin B12, Folate, and Homocysteine Blood Concentrations" in volume 84 on page 477.

Genome-wide association study of circulating vitamin D levels. About this Publication Title. Genome-wide association study of. osteoporosis, multiple sclerosis and cancer. In a genome-wide association study GWAS of 4501 persons of European ancestry drawn from five cohorts, we identified single-nucleotide polymorphisms SNPs in. Vitamin B6 är ett samlingsnamn för ämnena pyridoxin, pyridoxamin och pyridoxal. Pyridoxin kan också användas som samlingsnamn för dessa ämnen. Större delen av allt B6 ombildas till pyridoxinsyra och utsöndras med urinen, [1] eftersom det dagliga intaget ofta är högt och kroppen inte förmår lagra stora kvantiteter B6. We performed a genome-wide association study GWAS in 2,100 stroke patients from the Vitamin Intervention for Stroke Prevention VISP trial, a clinical trial designed to determine whether the daily intake of high-dose folic acid, vitamins B6, and B12 reduce recurrent cerebral infarction.

Genome-wide association study of circulating.

Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations. Tanaka T, Scheet P, Giusti B, Bandinelli S, Piras MG, Usala G, Lai S, Mulas A, Corsi AM, Vestrini A, Sofi F, Gori AM, Abbate R, Guralnik J, Singleton A, Abecasis GR, Schlessinger D,. BibTeX @MISCB_reportgenome-wide, author = Of Vitamin B and Vitamin B and Homocysteine Blood Concentrations and Toshiko Tanaka and Paul Scheet and Betti Giusti and Stefania B and Maria Grazia Piras and David Schlessinger and Manuela Uda and Luigi Ferrucci, title = REPORT Genome-wide Association Study, year = . Haptocorrin also known as transcobalamin-1 TC-1 or cobalophilin is a transcobalamin protein that in humans is encoded by the TCN1 gene. The essential function of haptocorrin is protection of the acid-sensitive vitamin B 12 while it moves through the stomach.

rs4654748. From SNPedia. Jump to:navigation, search. Orientation: plus: Stabilized:. Genome-wide Association Study of Vitamin B6, Vitamin B12, Folate, and Homocysteine Blood Concentrations Risk. PMID [PMID 19744961] Trait Folate pathway vitamin levels: Title Genome-wide significant predictors of metabolites in the one-carbon metabolism. B vitamins play an important role in homocysteine metabolism, with vitamin deficiencies resulting in increased levels of homocysteine and increased risk for stroke. We performed a genome-wide association study GWAS in 2,100 stroke patients from the Vitamin Intervention for Stroke Prevention VISP trial, a clinical trial designed to determine. The primary circulating form of vitamin D, 25-hydroxy-vitamin D 25OHD, is associated with multiple medical outcomes, including rickets, osteoporosis, multiple sclerosis, and cancer. In a genome-wide association study GWAS of 4,501 persons of European ancestry drawn from five cohorts, we identified single nucleotide polymorphisms SNPs in. 10/01/2018 · Homocysteine Hcy is a heritable biomarker for CVD, peripheral artery disease, stroke, and dementia. Little is known about genetic associations with Hcy in individuals of African ancestry. We performed a genome-wide association study for Hcy in 4927 AAs from the Jackson Heart Study JHS, the Multi-Ethnic Study of Atherosclerosis MESA, and. 16/06/2010 · Serum B Vitamin Levels and Risk of Lung Cancer. Independent and Combined Associations of Serum B6, Methionine,. Tanaka T, Scheet P, Giusti B, et al. Genome-wide association study of vitamin B 6, vitamin B 12, folate, and homocysteine blood concentrations. Am J.

  1. Genome-wide significant associations were observed for vitamin B6, B12, and homocysteine concentrations. Vitamin B6 was only measured in the InCHIANTI study, thus the GWA of 484,115 autosomal SNPs was assessed with a Bonferroni corrected p value threshold of 1 × 10 −7 Figure 1A and Figure S1 available online.
  2. 15/05/2009 · To investigate genetic factors that affect circulating vitamin B6, vitamin B12, folate and homocysteine, a genome-wide association analysis was conducted in the InCHIANTI N = 1175, SardiNIA N = 1115, and BLSA N = 640 studies. The top loci were replicated in an independent sample of 687 participants in the Progetto Nutrizione study.
  3. 01/04/2009 · Genome-wide significant associations were observed for vitamin B6, B12, and homocysteine concentrations. Vitamin B6 was only measured in the InCHIANTI study, thus the GWA of 484,115 autosomal SNPs was assessed with a Bonferroni corrected p value threshold of 1 × 10 −7 Figure 1 A and Figure S1 available online.
  4. Homocysteine, a by-product of OCM, has been associated with coronary heart disease, stroke and neurological disease. To investigate genetic factors that affect circulating vitamin B6, vitamin B12, folate and homocysteine, a genome-wide association analysis was conducted in the InCHIANTI N = 1175, SardiNIA N = 1115, and BLSA N = 640 studies.

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